| Synthesis of Folic Acid Conjugated Pluronic F127 and Their Morphology in Water |
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Writer: Shao Fang-ke, Wu Wei, Zha Liu-sheng, Zhang Yan Publication: ACTA CHIMICA SINICA. 2008, 66(1): 138-140 Abstract: Triblock copolymer Pluronic F127 was reacted with p-toluenesulfonyl chloride, potassium phthalimide and ethylenediamine in turn to modify the end hydroxyls of F127 to amino end groups. Using the amino end groups, the bioactive macromolecular folic acids were conjugated to the end group of F127 as the targeting ligand. 1H NMR and IR were adopted to characterize the structures of the folate-capped F127 copolymers. The micelle solutions of F127-folate were prepared by the dialysis method. The morphologies of the copolymers in water were investigated by TEM. The results proved that F127-folate could self-assemble into micelles in water.
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